| Name | Mitogen-activated protein kinase 11 | ||
| UniProt ID | MK11_HUMAN | ||
| Gene Name | MAPK11 | ||
| Gene ID | 5600 | ||
| Synonyms |
MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta
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| Sequence |
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL EIEQ |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 8.A.216.1.1 | ||
| KEGG ID | hsa5600 | ||
| TTD ID | T55729 | ||
| Pfam | PF00069; PF01163; PF01636; PF03109; PF06293; PF07714; PF09344; PF13095 | ||
| Pair Name | Gambogic Acid, Cisplatin | |||
| Phytochemical | Gambogic Acid | |||
| Drug | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Regulate Info | Down-regulation | Mitogen-activated protein kinase 11 | Phosphorylation | |
| Result | Gambogic acid sensitises lung cancer cells to CDDP in vitro and in vivo in NSCLC through inactivation of NF-κB and MAPK/HO-1 signalling pathways, providing a rationale for the combined use of CDDP and GA in lung cancer chemotherapy. | |||
