| Name | Interferon regulatory factor 3 | ||
| UniProt ID | IRF3_HUMAN | ||
| Gene Name | IRF3 | ||
| Gene ID | 3661 | ||
| Synonyms |
IRF3, IIAE7
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| Sequence |
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA
TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD FQGPGES |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa3661 | ||
| TTD ID | T38017 | ||
| Pfam | PF00605; PF10401 | ||
| Pair Name | Ginsenoside Rh2, Anti-PD-L1 antibody | |||
| Phytochemical | Ginsenoside Rh2 | |||
| Drug | Anti-PD-L1 antibody | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Regulate Info | Up-regulation | Interferon regulatory factor 3 | Phosphorylation | |
| Result | These findings demonstrated that Rh2 potentiated the anti-cancer effect of PD-L1 blockade via promoting the T cells infiltration and activation, which shed a new light on the combination strategy to enhance anti-PD-L1 immunotherapy by using natural product Rh2. | |||
