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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name HOXA distal transcript antisense RNA
UniProt ID /
Gene Name HOTTIP
Gene ID 100316868
Synonyms
HOXA-AS6, HOXA13-AS1, NCRNA00213
Sequence
/
TTD ID T61881
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 46
Ref_1
Pair Name Solamargine, Sorafenib
Phytochemical Solamargine
Drug Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Regulate Info Down-regulation HOXA distal transcript antisense RNA Expression
Result Our study revealed that SM inhibited the growth of HCC and enhanced the anticancer effect of SF through HOTTIP-TUG1/miR-4726-5p/MUC1 signaling pathway. These findings will provide potential therapeutic targets and strategies for the treatment of HCC.
03. Reference
No. Title Href
1 Solamargine inhibits the growth of hepatocellular carcinoma and enhances the anticancer effect of sorafenib by regulating HOTTIP-TUG1/miR-4726-5p/MUC1 pathway. Mol Carcinog. 2022 Apr;61(4):417-432. doi: 10.1002/mc.23389. Click
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