| Name | Histone acetyltransferase type B catalytic subunit | ||
| UniProt ID | HAT1_HUMAN | ||
| Gene Name | HAT1 | ||
| Gene ID | 8520 | ||
| Synonyms |
HAT1, KAT1
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| Sequence |
MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLF
GDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFC TNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQT FLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQ MLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCF SREKLMQGFNEDMVIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLI SPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa8520 | ||
| Pfam | PF00583; PF10394; PF13508; PF17279; PF21183 | ||
| Pair Name | Vitamin C, GW841819X | |||
| Phytochemical Name | Vitamin C | |||
| Anticancer drug Name | GW841819X | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Regulate Info | Down-regulation | Histone acetyltransferase type B catalytic subunit | Expression | |
| Result | This study shows that ascorbate can enhance the efficacy of BET inhibitors, providing a possible clinical solution to challenges arising in phase I trials from the dose-dependent side effects of this class of epigenetic therapy. | |||
