| Name | Histone H4 | ||
| UniProt ID | H4_HUMAN | ||
| Gene Name | H4C12 | ||
| Gene ID | 8362 | ||
| Synonyms |
H4C12, H4-16, H4/d, H4C1, H4C11, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2iii, H4FD, HIST1H4K, dJ160A22.1
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| Sequence |
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa8362 | ||
| Pfam | PF00125; PF00808; PF02291; PF02969; PF03677; PF07524; PF15511; PF15630 | ||
| Pair Name | Vitamin C, GW841819X | |||
| Phytochemical Name | Vitamin C | |||
| Anticancer drug Name | GW841819X | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Regulate Info | Down-regulation | Histone H4 | Expression | |
| Result | This study shows that ascorbate can enhance the efficacy of BET inhibitors, providing a possible clinical solution to challenges arising in phase I trials from the dose-dependent side effects of this class of epigenetic therapy. | |||
