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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Probable glutathione peroxidase 8
UniProt ID GPX8_HUMAN
Gene Name GPX8
Gene ID 493869
Synonyms
GPX8, EPLA847, GPx-8, GSHPx-8, UNQ847
Sequence
MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTV
SLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSK
EVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKF
WKPEEPIEVIRPDIAALVRQVIIKKKEDL
Pathway Map MAP LINK
KEGG ID hsa493869
Pfam PF00255; PF00578; PF08534; PF20403
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 1007
Pair Name Artesunate, TP-0903
Phytochemical Artesunate
Drug TP-0903
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Regulate Info Down-regulation Probable glutathione peroxidase 8 Expression
Result Synergistic interactions between TP-0903 and ART indicate that combination approaches involving these compounds can have therapeutic prospects for TNBC treatment.
03. Reference
No. Title Href
1 Mesenchymal-epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate. Sci Rep. 2024 Jan 3;14(1):425. doi: 10.1038/s41598-023-50710-3. Click
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