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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Protein Cripto
UniProt ID TDGF1_HUMAN
Gene Name CRIPTO
Gene ID 6997
Synonyms
CRIPTO, CR, CR-1, CRGF, TDGF1
Sequence
MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYLAFRDDSIWPQEEPAIR
PRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPH
DTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGI
CLSIQSYY
Pathway Map MAP LINK
T.C. Number 1.A.10.1.28; 3.A.1.201.1
KEGG ID hsa6997
TTD ID T47864
Pfam PF00008; PF07974; PF09443; PF12661
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 61
Pair Name Luteolin, Paclitaxel
Phytochemical Luteolin
Drug Paclitaxel
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Regulate Info Down-regulation Protein Cripto Expression
Result These findings suggest that luteolin treatment significantly attenuated the hallmarks of breast cancer stemness by downregulating Nrf2-mediated expressions. Luteolin constitutes a potential agent for use in cancer stemness-targeted breast cancer treatments.
03. Reference
No. Title Href
1 Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway. Molecules. 2021 Oct 26;26(21):6452. doi: 10.3390/molecules26216452. Click
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