| Name | E3 ubiquitin-protein ligase Hakai | ||
| UniProt ID | HAKAI_HUMAN | ||
| Gene Name | CBLL1 | ||
| Gene ID | 79872 | ||
| Synonyms |
CBLL1, HAKAI, RNF188
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| Sequence |
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE
EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH PDQTRYRPYYQ |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa79872 | ||
| Pfam | PF00097; PF02891; PF07191; PF13445; PF13639; PF13923; PF14634; PF18408 | ||
| Pair Name | Celastrol, Docetaxel | |||
| Phytochemical | Celastrol | |||
| Drug | Docetaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Regulate Info | Down-regulation | E3 ubiquitin-protein ligase Hakai | Expression | |
| Result | Our results showing anti-migratory/anti-invasive effects of celastrol and associated mechanisms provide new evidence for the development of celastrol as a potential anti-metastatic compound against highly aggressive breast cancer, and celastrol in combination with docetaxel might potentially be used as a novel regimen for the treatment of TNBC. | |||
