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8 beta-hydroasterolide, atractylenolide III, codonolactone

No.	Title	Href
1	Atractylenolide III Enhances the Anti-Neoplastic Efficacy of Docetaxel in Gastric Cancer Cell by Inhibiting Fibroblast Growth Factor Receptors 1, -2, and -4 Expression. J Environ Pathol Toxicol Oncol. 2019;38(3):217-227. doi: 10.1615/JEnvironPatholToxicolOncol.2019029196.	`Click`

No.

Title

Href

Atractylenolide III Enhances the Anti-Neoplastic Efficacy of Docetaxel in Gastric Cancer Cell by Inhibiting Fibroblast Growth Factor Receptors 1, -2, and -4 Expression. J Environ Pathol Toxicol Oncol. 2019;38(3):217-227. doi: 10.1615/JEnvironPatholToxicolOncol.2019029196.

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Name	Atractylenolide-III
PubChem CID	155948
Molecular Weight	248.32g/mol
Synonyms	8 beta-hydroasterolide, atractylenolide III, codonolactone
Formula	C₁₅H₂₀O₃
SMILES	CC1=C2CC3C(=C)CCCC3(CC2(OC1=O)O)C
InChI	1S/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1
InChIKey	FBMORZZOJSDNRQ-GLQYFDAESA-N
CAS Number	73030-71-4
ChEMBL ID	CHEMBL486961
ChEBI ID	CHEBI:69958
KEGG ID	C17887
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BaiZhu
Use Part	Root
Habitat	AnHui, ZheJiang, JiangXi
Flavor	Sweet; Bitter
Meridian Tropism	Spleen; Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asterales 　　　　-->Family: Asteraceae 　　　　　-->Genus: Atractylodes 　　　　　　-->Species: Atractylodes macrocephala

Pair Name	Atractylenolide-III, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	FGFR1	hsa2260
	Down-regulation	Expression	FGFR2	hsa2263
	Down-regulation	Expression	FGFR4	hsa2264
In Vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
Result	ATL and docetaxel treatment performed the synergistic effects on the inhibition of growth and induction of apoptosis in gastric cancer cells, and the underlying mechanism was mediated, at least partially, through the inhibition of FGFR1, -2, and -4.