| Name | Amphiregulin | ||
| UniProt ID | AREG_HUMAN | ||
| Gene Name | AREG | ||
| Gene ID | 374 | ||
| Synonyms |
AREG, AR, AREGB, CRDGF, SDGF
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| Sequence |
MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG
SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK LRQENGNVHAIA |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa374 | ||
| TTD ID | T92834 | ||
| Pfam | PF00008; PF04999 | ||
| Pair Name | Sanguinarium, Cisplatin | |||
| Phytochemical | Sanguinarium | |||
| Drug | Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Regulate Info | Down-regulation | Amphiregulin | Expression | |
| Result | Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM. | |||
