| Name | Adhesion G protein-coupled receptor L4 | ||
| UniProt ID | AGRL4_HUMAN | ||
| Gene Name | ADGRL4 | ||
| Gene ID | 64123 | ||
| Synonyms |
ADGRL4, ELTD1, ETL, KPG_003
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| Sequence |
MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYCNMGFSGNGVTICEDDN
ECGNLTQSCGENANCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNV CIAANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTI SAKDTLSNSTLTEFVKTVNNFVQRDTFVVWDKLSVNHRRTHLTKLMHTVEQATLRISQSF QKTTEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDGDYINIFPKRKAAYDSNGNVAVAFV YYKSIGPLLSSSDNFLLKPQNYDNSEEEERVISSVISVSMSSNPPTLYELEKITFTLSHR KVTDRYRSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGPSIG IKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVG INTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLS PAVVVGFSAALGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHT AGLKPEVSCFENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFI FLFLCVLSRKIQEEYYRLFKNVPCCFGCLR |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 9.A.14.6.3 | ||
| KEGG ID | hsa64123 | ||
| Pfam | PF00002; PF01825; PF07645; PF12662; PF12946; PF12947; PF16489 | ||
| Pair Name | Tanshinone IIA, Anti-mouse PD-1 | |||
| Phytochemical | Tanshinone IIA | |||
| Drug | Anti-mouse PD-1 | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Adhesion G protein-coupled receptor L4 | Expression | |
| Result | This study reveals a new mechanism between TSA and ELTD1 for vascular normalization, suggesting that therapeutic or pharmacological intervention with ELTD1 may enhance the efficacy of PD-1 inhibitors in HCC. | |||
