Drug General Information
| Drug Name |
Alpelisib
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| Synonyms |
alpelisib; 1217486-61-7; BYL-719; BYL719; UNII-08W5N2C97Q; BYL 719; Alpelisib (BYL719); (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; NVP-BYL719; (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide; CHEMBL2396661; 08W5N2C97Q; AK146107; C19H22F3N5O2S; (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide
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| Drug Type |
Small molecular drug
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| Indications |
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
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Phase 2
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Breast cancer [ICD-11: 2C60-2C65]
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Approved
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| Company |
Novartis
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| Summary |
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity.
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| Target |
PI3-kinase alpha (PIK3CA)
Mechanism of Action: Inhibitor
|
T80276 | |
Drug Chemical Infomation and External Links
|
Formula |
C19H22F3N5O2S
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| Canonical SMILES |
CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
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| InChI |
1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
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| InChIKey |
STUWGJZDJHPWGZ-LBPRGKRZSA-N
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| CAS Number | CAS 1217486-61-7 | |
| TTD ID | D0W7HE | |
| DrugBank ID | DB12015 | |
| PubChem Compound ID | 56649450 | |
| PubChem Substance ID |
134426754
,
140722288
,
152159632
,
152255399
,
152258655
,
160647491
,
162012035
,
163643246
,
164041693
,
172918746
,
174486688
,
174861534
,
175448776
,
176251621
,
185965275
,
198967672
,
215785718
,
223382725
,
223626250
,
225848216
,
228076739
,
244202215
,
249565638
,
252214078
,
252451646
,
252470926
|
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| ChEBI ID | CHEBI:93752 | |
| ADReCS Drug ID | BADD_D02500 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |