Drug ID: D01123

Drug General Information

Drug Name
Fedratinib
Synonyms
TG101348
Drug Type
Small molecular drug
Indications
Myelofibrosis [ICD-11: 2A20.2]
Approved
Company
Targen
Summary
Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis. It is an anilinopyrimidine derivative.
Target
Janus kinase 2 (JAK-2)
Mechanism of Action: Inhibitor
 T08391

Drug Chemical Infomation and External Links

Download MOL File
Formula
C27H36N6O3S
Canonical SMILES
CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
InChI
1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
InChIKey
JOOXLOJCABQBSG-UHFFFAOYSA-N
CAS Number CAS 936091-26-8
TTD ID D0G8BM
DrugBank ID DB12500
PubChem Compound ID 16722836
PubChem Substance ID
26676801 , 30579298 , 46561094 , 123051066 , 123055414 , 123089189 , 123111409 , 124772137 , 125570859 , 126636399 , 126731489 , 134339444 , 136340331 , 136349576 , 136367707 , 136920419 , 137275863 , 137542912 , 151982040 , 152258205 , 152344250 , 160647041 , 162011416 , 162038114 , 162205108 , 163642944 , 163912758 , 164194009 , 172131313 , 172659575 , 172914566 , 173906115 , 174561102 , 177748637 , 178102342 , 180387006 , 185969763 , 198945651 , 223438203 , 223685670 , 223705188 , 226611600 , 242564675 , 243245113 , 249583068 , 251971400 , 252160278 , 252216457 , 252450319 , 252543375
ChEBI ID CHEBI:91408
ADReCS Drug ID NA

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification