Drug ID: D01052

Drug General Information

Drug Name
Selumetinib
Synonyms
Selumetinib; AZD-6244; ARRY142886; AZD6244; ARRY142886; AZD 6244; AZD-6244; 6UH91I579U; ARRY 142886; ARRY-142886; AZD6244 (Selumetinib); AZD6244(Selumetinib); CHEBI:90227; CHEMBL1614701; MEK inhibitors; Selumetinib (AZD6244); UNII-6UH91I579U
Drug Type
Small molecular drug
Indications
Non-small-cell lung cancer [ICD-11: 2C25.Y]
Phase 2
Melanoma [ICD-11: 2C30]
Phase 3
Thyroid cancer [ICD-11: 2D10]
Phase 3
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Investigative
Company
AstraZeneca
Summary
Selumetinib is a MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN).
Target
MAPK/ERK kinase kinase (MAP3K)
Mechanism of Action: Modulator
 T23003
ERK activator kinase 2 (MEK2)
Mechanism of Action: Inhibitor
 T89055
ERK activator kinase 1 (MEK1)
Mechanism of Action: Inhibitor
 T35940

Drug Chemical Infomation and External Links

Download MOL File
Formula
C17H15BrClFN4O3
Canonical SMILES
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
InChI
1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey
CYOHGALHFOKKQC-UHFFFAOYSA-N
CAS Number CAS 606143-52-6
TTD ID D0T5DP
DrugBank ID DB11689
PubChem Compound ID 10127622
PubChem Substance ID
15117183 , 22530930 , 39966063 , 53837732 , 57374224 , 76853338 , 91146061 , 99431772 , 123051124 , 124490406 , 124756930 , 124899407 , 124963590 , 125163737 , 125329930 , 125569760 , 126580498 , 126644899 , 126665950 , 126737693 , 131465101 , 131477688 , 135262198 , 135344948 , 135602608 , 135685252 , 135685253 , 135685272 , 135686160 , 135686161 , 135686182 , 135686183 , 135727389 , 136368075 , 136920282 , 136959521 , 137220034 , 139721905 , 143499011 , 144115657 , 144206913 , 152043674 , 152235945 , 152258818 , 152344235 , 160647668 , 160813024 , 162011399 , 162037381 , 162200063
ChEBI ID CHEBI:90227
ADReCS Drug ID NA

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification