Drug General Information
| Drug Name |
Vortioxetine
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| Synonyms |
VORTIOXETINE; 508233-74-7; 1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine; Lu AA21004; UNII-3O2K1S3WQV; 3O2K1S3WQV; CHEBI:76016; Trintellix; 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine; Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-; Brintellix (TN); 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine; 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine; 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; CHEMBL2204360; 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine; Lu-AA21004
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| Drug Type |
Small molecular drug
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| Indications |
Mood disorder [ICD-11: 6A60-6E23]
|
Phase 3
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|
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Major depressive disorder [ICD-11: 6A70.3]
|
Approved
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| Company |
Lundbeck; Takeda Pharmaceuticals
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| Summary |
Vortioxetine is a serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD).
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| Target |
Serotonin transporter (SERT)
Mechanism of Action: Inhibitor
|
T27812 | |
Drug Chemical Infomation and External Links
|
Formula |
C18H22N2S
|
| Canonical SMILES |
CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C
|
|
| InChI |
1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
|
|
| InChIKey |
YQNWZWMKLDQSAC-UHFFFAOYSA-N
|
|
| CAS Number | CAS 508233-74-7 | |
| TTD ID | D03WEX | |
| DrugBank ID | DB09068 | |
| PubChem Compound ID | 9966051 | |
| PubChem Substance ID |
14942974
,
24232104
,
46062622
,
74967215
,
134339122
,
135268324
,
135626902
,
137031414
,
141291936
,
160676538
,
160874200
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162224457
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163349926
,
163409417
,
163847660
,
164347389
,
164777223
,
172919848
,
175266271
,
178103923
,
185968494
,
187072019
,
189628085
,
198993777
,
210024065
,
210275229
,
210280867
,
223595856
,
224449304
,
226587298
,
242073286
,
244850411
,
249828940
,
250182630
,
251899315
,
252055744
,
252090010
,
252313288
,
252499412
|
|
| ChEBI ID | CHEBI:76016 | |
| ADReCS Drug ID | BADD_D02371 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |