Drug ID: D00998

Drug General Information

Drug Name
Ambrisentan
Synonyms
Letairis; Ambrisentan [INN]; Gilead brand of ambrisentan; BSF 208075; BSF208075; LU 208075; LU208075; BSF-208075; LU-208075; Benzenepropanoic acid, .alpha.-[(4,6-dimethyl-2-pyrimidinyl)oxy]-.beta.-methoxy-.beta.-phe; (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid; 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
Drug Type
Small molecular drug
Indications
Pulmonary arterial hypertension [ICD-11: BB01.0]
Approved
Company
GSK
Summary
Ambrisentan is a selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications.
Target
Endothelin A receptor (EDNRA)
Mechanism of Action: Antagonist
 T23499

Drug Chemical Infomation and External Links

Download MOL File
Formula
C22H22N2O4
Canonical SMILES
CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI
1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey
OUJTZYPIHDYQMC-LJQANCHMSA-N
CAS Number CAS 177036-94-1
TTD ID D0X5ZI
DrugBank ID DB06403
PubChem Compound ID 6918493
PubChem Substance ID
12015371 , 14779987 , 17194924 , 43529863 , 50551569 , 51091419 , 53787770 , 57371956 , 93309673 , 103307060 , 104035299 , 114788055 , 118855302 , 126616865 , 126651844 , 131302629 , 134338642 , 135692418 , 137237404 , 139988399 , 143497715 , 144205520 , 152133959 , 152238501 , 152258462 , 160647297 , 160826914 , 162011508 , 162172038 , 163093066 , 163387054 , 164824132 , 170465143 , 174007223 , 175267375 , 175426501 , 178100778 , 179116973 , 185986582 , 187071933 , 196107821 , 198977886 , 198991664 , 204430246 , 211534802 , 223375980 , 223532574 , 223704800 , 224518792 , 226395806
ChEBI ID CHEBI:135949
ADReCS Drug ID BADD_D00100

Drug-Food (Herb) Interactions

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  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification