Drug General Information
| Drug Name |
Everolimus
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| Synonyms |
Afinitor; Afinitor (TN); CERTICAN(R); Certican; Certican (TN); Everolimus (JAN/USAN/INN); Everolimus [USAN]; MTOR kinase inhibitors; NVP-RAD-001; RAD 001; RAD-001; RAD-001C; RAD001; RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus; SDZ-RAD; Zortress
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| Drug Type |
Small molecular drug
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| Indications |
Renal cell carcinoma [ICD-11: 2C90]
|
Approved
|
|
|
Kidney cancer [ICD-11: 2C90.0]
|
Phase 3
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| Company |
Novartis
|
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| Summary |
Everolimus is a mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
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| Target |
Serine/threonine-protein kinase mTOR (mTOR)
Mechanism of Action: Inhibitor
|
T75243 | |
Drug Chemical Infomation and External Links
|
Formula |
C53H83NO14
|
| Canonical SMILES |
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
|
|
| InChI |
1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
|
|
| InChIKey |
HKVAMNSJSFKALM-GKUWKFKPSA-N
|
|
| CAS Number | CAS 159351-69-6 | |
| TTD ID | D0K3QS | |
| DrugBank ID | DB01590 | |
| PubChem Compound ID | 6442177 | |
| PubChem Substance ID |
12014881
,
14767667
,
14865574
,
50044230
,
50112765
,
56311446
,
56312241
,
56312580
,
56313164
,
91613187
,
104178966
,
134338463
,
135156085
,
136340120
,
136929859
,
137140572
,
139754909
,
143493384
,
144206063
,
151990396
,
152236848
,
152258132
,
160645716
,
160646971
,
162189189
,
174527790
,
175265707
,
177748738
,
179150022
,
203355779
,
226396389
|
|
| ChEBI ID | CHEBI:68478 | |
| ADReCS Drug ID | BADD_D00858 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |