Drug General Information
| Drug Name |
Cefepime
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| Synonyms |
Axepim; CFPM; Cefepima; Cefepimum; Cepimax; Cepimex; Maxcef; Maxipime; Cefepima [Spanish]; Cefepimum [Latin]; BMY 28142; Axepim (TN); BMY-28142; Cefepime [USAN:INN]; Cepimax (TN); Cepimex (TN); Maxcef (TN); Maxipime (TN); Cefepime (USAN/INN); (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methylpyrrolidinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime); 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylate
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| Drug Type |
Small molecular drug
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| Indications |
Bacterial infection [ICD-11: 1A00-1C4Z]
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Approved
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| Company |
Bristol-Myers Squibb
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| Summary |
Cefepime is a fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.
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| Target |
Bacterial Penicillin binding protein 2 (Bact mrdA)
Mechanism of Action: Modulator
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T66040 | |
Drug Chemical Infomation and External Links
|
Formula |
C19H24N6O5S2
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| Canonical SMILES |
C[N+]1(CCCC1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-]
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| InChI |
1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
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| InChIKey |
HVFLCNVBZFFHBT-ZKDACBOMSA-N
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|
| CAS Number | CAS 88040-23-7 | |
| TTD ID | D0A1CB | |
| DrugBank ID | DB01413 | |
| PubChem Compound ID | 5479537 | |
| PubChem Substance ID |
10311
,
7849435
,
7978874
,
11693490
,
12012932
,
14932491
,
39470231
,
46507919
,
50065351
,
71822559
,
75646007
,
85667296
,
92308934
,
96099915
,
103511405
,
104133795
,
113985968
,
124766014
,
126591202
,
131329038
,
134337750
,
135028794
,
136357156
,
136368000
,
137003427
,
141312379
,
144115806
,
151990284
,
152344317
,
160964682
,
163693508
,
163853059
,
164788231
,
175268534
,
176484072
,
179151369
,
196378891
,
226446822
,
241151996
,
251916740
,
251917979
,
252820711
|
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| ChEBI ID | CHEBI:478164 | |
| ADReCS Drug ID | BADD_D00386 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
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| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |