Drug General Information
| Drug Name |
Sirolimus
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| Synonyms |
53123-88-9; Rapamune; Rapamycin (Sirolimus); AY-22989; Rapammune; sirolimusum; WY-090217; RAPA; Antibiotic AY 22989; AY 22989; UNII-W36ZG6FT64; CCRIS 9024; CHEBI:9168; SILA 9268A; W36ZG6FT64; HSDB 7284; C51H79NO13; NSC 226080; DE-109; NCGC00021305-05; DSSTox_CID_3582; DSSTox_RID_77091; DSSTox_GSID_23582; Cypher; Supralimus; Wy 090217; Perceiva; RAP; RPM; Rapamycin from Streptomyces hygroscopicus; SIIA 9268A; LCP-Siro; MS-R001; Rapamune (TN); Rapamycin (TN); Sirolimus (RAPAMUNE); Rapamycin C-7, analog 4; Sirolimus (USAN/INN); Sirolimus [USAN:BAN:INN]; Sirolimus, Rapamune,Rapamycin; Heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy; 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; 23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29; 3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; Sirolimus (MTOR inhibitor)
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| Drug Type |
Small molecular drug
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| Indications |
Dutch elm disease [ICD-11: 8D64]
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Phase 1/2
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|
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Organ transplant rejection [ICD-11: NE84]
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Approved
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Multiple myeloma [ICD-11: 2A83]
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Approved
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| Company |
Wyeth
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| Summary |
Sirolimus is an mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.
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| Target |
PI3K/AKT/mTOR pathway (PAm pathway)
Mechanism of Action: Inhibitor
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T90695 | |
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Serine/threonine-protein kinase mTOR (mTOR)
Mechanism of Action: Inhibitor
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T75243 | ||
Drug Chemical Infomation and External Links
|
Formula |
C51H79NO13
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| Canonical SMILES |
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
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| InChI |
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
|
|
| InChIKey |
QFJCIRLUMZQUOT-HPLJOQBZSA-N
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|
| CAS Number | CAS 53123-88-9 | |
| TTD ID | D03LJR | |
| DrugBank ID | DB00877 | |
| PubChem Compound ID | 5284616 | |
| PubChem Substance ID |
636884
,
830671
,
7890221
,
7982025
,
8145920
,
11110132
,
11110134
,
11110139
,
11528741
,
12014635
,
14816423
,
14816426
,
24430811
,
24899339
,
26701762
,
26705530
,
26705537
,
26709840
,
26713306
,
37101833
,
46391895
,
46392864
,
47289337
,
48416541
,
49635682
,
49815675
,
50103901
,
50139515
,
56310631
,
56310880
,
56311583
,
56311585
,
56311714
,
56311827
,
56311949
,
56311983
,
56312137
,
56312183
,
56312184
,
56312185
,
56312186
,
56312645
,
56312887
,
56313330
,
56313354
,
56313375
,
56313498
,
56313803
,
56313974
,
56314022
|
|
| ChEBI ID | CHEBI:9168 | |
| ADReCS Drug ID | BADD_D02028 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
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| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |