Drug General Information
| Drug Name |
Tacrolimus
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| Synonyms |
Advagraf; Fujimycin; Graceptor; Modigraf; Prograf; Protopic; Protopy; Tacarolimus; Tsukubaenolide; Tacrolimus anhydrous; FK 506; FK5; FK506; FR 900506; FR900506; K506; L 679934; Advagraf (TN); FR-900506; Fk-506; L-679934; LCP-Tacro; Prograf (TN); Protopic (TN); Tacrolimus (INN); Tacrolimus (Prograf); Tacrolimus (anhydrous); (-)-FK 506; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
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| Drug Type |
Small molecular drug
|
||
| Indications |
Ocular allergy [ICD-11: 4A81]
|
Phase 3
|
|
|
Organ transplant rejection [ICD-11: NE84]
|
Approved
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| Company |
Fujisawa; Sucampo
|
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| Summary |
Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
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| Target |
Calcineurin (PPP3CA)
Mechanism of Action: Inhibitor
|
T25464 | |
Drug Chemical Infomation and External Links
|
Formula |
C44H69NO12
|
| Canonical SMILES |
CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
|
|
| InChI |
1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
|
|
| InChIKey |
QJJXYPPXXYFBGM-LFZNUXCKSA-N
|
|
| CAS Number | CAS 104987-11-3 | |
| TTD ID | D06OMK | |
| DrugBank ID | DB00864 | |
| PubChem Compound ID | 445643 | |
| PubChem Substance ID |
4572
,
832905
,
842004
,
7887491
,
7980719
,
8150098
,
10299743
,
12013904
,
14815954
,
14889261
,
24841759
,
26703416
,
26705532
,
26705535
,
26713140
,
26715494
,
26756858
,
29216422
,
36888289
,
46506004
,
47574395
,
48020022
,
50111459
,
50111460
,
53788265
,
57404698
,
74380484
,
76558282
,
85788970
,
91011629
,
92308089
,
92310166
,
92711966
,
96025241
,
99301078
,
99302128
,
99436940
,
103164549
,
103939344
,
104178757
,
104222107
,
104634734
,
109693101
,
118048657
,
119525750
,
124757870
,
124766122
,
124892446
,
124892447
,
124892448
|
|
| ChEBI ID | CHEBI:61049 | |
| ADReCS Drug ID | BADD_D02105 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |