Drug ID: D00747

Drug General Information

Drug Name
Lacosamide
Synonyms
Erlosamide; Harkoseride; Vimpat; Erlosamide [INN]; Lacosamide [USAN]; ADD 234037; SPM 927; ADD-234037; SPM-927; SPM-929; Erlosamide, Vimpat, Lacosamide; Lacosamide (USAN/INN); (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
Drug Type
Small molecular drug
Indications
Convulsion [ICD-11: 8A68.Z]
Approved
Epilepsy [ICD-11: 8A60-8A68]
Approved
Diabetic neuropathy [ICD-11: 8C0Z]
Phase 3
Company
Schwarz Pharma
Summary
Lacosamide is an antiepileptic drug used to treat partial onset seizures in adults.
Target
Dihydropyrimidinase related protein 2 (DPYSL2)
Mechanism of Action: Modulator
 T92078
Voltage-gated sodium channel alpha Nav1.9 (SCN11A)
Mechanism of Action: Inhibitor
 T34123
Voltage-gated sodium channel (Nav)
Mechanism of Action: Inhibitor
 T72065

Drug Chemical Infomation and External Links

Download MOL File
Formula
C13H18N2O3
Canonical SMILES
CC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
InChI
1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
InChIKey
VPPJLAIAVCUEMN-GFCCVEGCSA-N
CAS Number CAS 175481-36-4
TTD ID D05OFX
DrugBank ID DB06218
PubChem Compound ID 219078
PubChem Substance ID
9374274 , 12015335 , 14847708 , 15196715 , 30422445 , 50069298 , 51091636 , 53505872 , 57399840 , 58107206 , 99218530 , 99298399 , 99437053 , 103245465 , 104154565 , 109693474 , 113468551 , 123121578 , 124757118 , 125163922 , 126575044 , 126624062 , 126644682 , 126667072 , 126733504 , 129508865 , 134339319 , 135141960 , 135367753 , 135697647 , 135707761 , 136895303 , 136991060 , 137237313 , 137237672 , 139113413 , 152258417 , 160647253 , 160660621 , 160826045 , 162037520 , 162188094 , 163092695 , 163589394 , 164824528 , 170466190 , 172086321 , 174006177 , 174527897 , 175266112
ChEBI ID CHEBI:135939
ADReCS Drug ID BADD_D01238

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification