Drug General Information
| Drug Name |
Methotrexate
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| Synonyms |
methotrexate; 1959/5/2; Rheumatrex; Amethopterin; Metatrexan; Hdmtx; Abitrexate; Mexate; Methylaminopterinum; Methotrexatum; Antifolan; Metotrexato; Methylaminopterin; MTX; (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid; Methotrexat; Amethopterine; Maxtrex; Rasuvo; L-Amethopterin; A-Methopterin; A-Methpterin; Amethopterin L-; Folex-Pfs; Methotrexat-Ebewe; N-Bismethylpteroylglutamic acid; Methotrexate, L-; Metotressato [DCIT]; Methotextrate; Mexate-Aq; [3H]methotrexate
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| Drug Type |
Small molecular drug
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| Indications |
leukaemia [ICD-11: 2A60-2B33]
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Approved
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Prostate cancer [ICD-11: 2C82.0]
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Investigative
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Proliferative vitreoretinopathy [ICD-11: 9B78.2]
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Phase 3
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Rheumatoid arthritis [ICD-11: FA20]
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Phase 1
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Solid tumour/cancer [ICD-11: 2A00-2F9Z]
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Phase 3
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| Company |
NA
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| Summary |
Methotrexate is an antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
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| Target |
Proton-coupled folate transporter (SLC46A1)
Mechanism of Action: Modulator
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T19229 | |
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Solute carrier family 19 member 1 (SLC19A1)
Mechanism of Action: Modulator
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T35465 | ||
Drug Chemical Infomation and External Links
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Formula |
C20H22N8O5
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| Canonical SMILES |
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
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| InChI |
1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
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| InChIKey |
FBOZXECLQNJBKD-ZDUSSCGKSA-N
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| CAS Number | CAS 59-05-2 | |
| TTD ID | D0SV8E | |
| DrugBank ID | DB00563 | |
| PubChem Compound ID | 126941 | |
| PubChem Substance ID |
NA
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| ChEBI ID | CHEBI:44185 | |
| ADReCS Drug ID | BADD_D01418 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
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| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |