Drug ID: D00674

Drug General Information

Drug Name
Nitisinone
Synonyms
Nitisinona; Nitisinonum; Nitisone; Orfadin; Nitisinone [INN]; SC 0735; FE-0200; Nitisinone (NTBC); Nitisinone [USAN:INN]; Orfadin (TN); Nitisinone (JAN/USAN/INN); 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione
Drug Type
Small molecular drug
Indications
Hereditary tyrosinemia type 1 [ICD-11: 5C50.11]
Approved
Company
NA
Summary
Nitisinone is a hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods.
Target
Hydroxyphenylpyruvate dioxygenase (HPD)
Mechanism of Action: Inhibitor
 T07137

Drug Chemical Infomation and External Links

Download MOL File
Formula
C14H10F3NO5
Canonical SMILES
C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
InChI
1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChIKey
OUBCNLGXQFSTLU-UHFFFAOYSA-N
CAS Number CAS 104206-65-7
TTD ID D0V1UW
DrugBank ID DB00348
PubChem Compound ID 115355
PubChem Substance ID
10236750 , 14753104 , 29296848 , 46507380 , 47206901 , 49957875 , 50139362 , 56311852 , 57339133 , 76271421 , 93167147 , 102979918 , 103425313 , 103987675 , 104398189 , 123051096 , 124758249 , 124896666 , 125432673 , 126666671 , 128861885 , 131293388 , 134223796 , 134338059 , 135072534 , 136340345 , 137003783 , 140881929 , 143500522 , 152030782 , 152134009 , 152227462 , 152248599 , 152344367 , 160821612 , 160963695 , 162011463 , 162165008 , 162203592 , 163091628 , 163372627 , 163775323 , 164045265 , 164175197 , 164216726 , 164763350 , 165702339 , 174007248 , 174525942 , 175268251
ChEBI ID CHEBI:50378
ADReCS Drug ID BADD_D01572

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification