Drug General Information
| Drug Name |
Amprenavir
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| Synonyms |
AMV; Agenerase; Amprenavir[usan]; Prozei; Vertex; Amprenavir [USAN]; VX 478; VX478; Vertex VX478; Agenerase (TM); Agenerase (TN); DRG-0258; GNA & Amprenavir; HHA & Amprenavir; KVX-478; VX-478; Amprenavir (JAN/USAN/INN); Tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate; {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER; [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester & Galanthus nivalis agglutinin (GNA); Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester & Hippeastrum hybrid agglutinin(HHA); (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate; (3S)-Tetrahydro-3-furyl ((alphaS)-alpha-((1R-1-hydroxy-2-(N(sup 1)-isobutylsulfanilamido)ethyl)phenethyl)carbamate; (3S)-tetrahydro-3-furyl N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxy-propyl]carbamate; (3S-(3R*(1R*,2S*)))-(3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl) tetrahydro-3-furanyl carbamate; 4-Amino-N-((2 syn,3S)-2-hydroxy-4-phenyl-3-((S)-tetrahydrofuran-3-yloxycarbonylamino)-butyl)-N-isobutyl-benzenesulfonamide
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| Drug Type |
Small molecular drug
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| Indications |
Human immunodeficiency virus infection [ICD-11: 1C62]
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Approved
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| Company |
GlaxoSmithKline
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| Summary |
Amprenavir is a protease inhibitor used to treat HIV infection.
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| Target |
Human immunodeficiency virus Protease (HIV PR)
Mechanism of Action: Inhibitor
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T56915 | |
Drug Chemical Infomation and External Links
|
Formula |
C25H35N3O6S
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| Canonical SMILES |
CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N
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|
| InChI |
1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1
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| InChIKey |
YMARZQAQMVYCKC-OEMFJLHTSA-N
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| CAS Number | CAS 161814-49-9 | |
| TTD ID | D0A0OO | |
| DrugBank ID | DB00701 | |
| PubChem Compound ID | 65016 | |
| PubChem Substance ID |
10286
,
601727
,
628182
,
822019
,
3727052
,
3727059
,
7847958
,
7885327
,
7978703
,
8030478
,
8189448
,
11528777
,
12014852
,
14835820
,
14884574
,
26697364
,
29215412
,
43121862
,
46392146
,
46393211
,
46507537
,
53790789
,
57315242
,
71821412
,
74965413
,
85177028
,
85177034
,
85177055
,
92309266
,
93166556
,
97857368
,
99239834
,
99239838
,
99239842
,
99239846
,
99239847
,
99239854
,
99239856
,
103179760
,
104178998
,
104253275
,
104332645
,
104829267
,
117549941
,
118048728
,
125267472
,
125310993
,
127310203
,
127310204
,
127310205
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| ChEBI ID | CHEBI:40050 | |
| ADReCS Drug ID | BADD_D00136 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
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| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |