Drug ID: D00600

Drug General Information

Drug Name
Irinotecan
Synonyms
Biotecan; Camptosar; Irinotecanum; IRINOTECAN HYDROCHLORIDE Trihydrate; Irinotecan Hcl; Irinotecan hydrochloride; CP0; Biotecan (TN); Campto (TN); Camptosar (TN); Irinotecan (INN); Irinotecan [INN:BAN]; Irinotecanum [INN-Latin]; IRINOTECAN, CPT-11; Camptosar, Campto, CPT-11, Irinotecan; (+)-Irinotecan; (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE; (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate; Irinotecan (TOPO1 inhibitor); Onivyde
Drug Type
Small molecular drug
Indications
Colorectal cancer [ICD-11: 2B91.Z]
Approved
Company
Pfizer Pharmaceuticals
Summary
Irinotecan is an antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum.
Target
DNA topoisomerase I (TOP1)
Mechanism of Action: Modulator
 T09826

Drug Chemical Infomation and External Links

Download MOL File
Formula
C33H38N4O6
Canonical SMILES
CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
InChI
1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
InChIKey
UWKQSNNFCGGAFS-XIFFEERXSA-N
CAS Number CAS 97682-44-5
TTD ID D07HOB
DrugBank ID DB00762
PubChem Compound ID 60838
PubChem Substance ID
645391 , 6436484 , 7886725 , 7979640 , 8187089 , 11409441 , 14764625 , 14911520 , 43118176 , 46393294 , 46505871 , 47811029 , 48427687 , 49835834 , 49894524 , 50422254 , 51090967 , 53788707 , 56312891 , 56314523 , 57288560 , 57314141 , 81092817 , 85789488 , 92711320 , 96024776 , 103169165 , 104020044 , 104253165 , 104321776 , 117623718 , 118049657 , 124757074 , 124893595 , 125163878 , 126630981 , 126650121 , 126663759 , 129430288 , 134337937 , 134338553 , 135032920 , 136342503 , 137001856 , 142371089 , 143493285 , 143493286 , 144116083 , 152034388 , 152240238
ChEBI ID CHEBI:80630
ADReCS Drug ID BADD_D01195

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification