Drug ID: D00594

Drug General Information

Drug Name
Gemcitabine
Synonyms
Gemcitabine hydrochloride; DDFC; DFdC; DFdCyd; Folfugem; GEO; Gamcitabine; GemLip; Gemcel; Gemcin; Gemcitabina; Gemcitabinum; Gemtro; Gemzar; Zefei; Gemcitabine HCl; Gemcitabine stereoisomer; LY 188011; LY188011; Gemcitabina [INN-Spanish]; Gemcitabinum [INN-Latin]; Gemzar (TN); Gemzar (hydrochloride); Inno-D07001; LY-188011; Gemcitabine (USAN/INN)
Drug Type
Small molecular drug
Indications
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Approved
Company
Eli Lilly
Summary
Gemcitabine is a nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
Target
Ribonucleoside-diphosphate reductase M2 (RRM2)
Mechanism of Action: Modulator
 T38301

Drug Chemical Infomation and External Links

Download MOL File
Formula
C9H11F2N3O4
Canonical SMILES
C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F
InChI
1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1
InChIKey
SDUQYLNIPVEERB-QPPQHZFASA-N
CAS Number CAS 95058-81-4
TTD ID D03UVS
DrugBank ID DB00441
PubChem Compound ID 60750
PubChem Substance ID
9852 , 597200 , 829253 , 7849427 , 7887820 , 7979381 , 8187035 , 15197115 , 15221618 , 24769903 , 24875076 , 43118104 , 46506425 , 49684285 , 49835789 , 49960194 , 50298729 , 53787881 , 56311575 , 56312523 , 56312627 , 56312648 , 56313191 , 56313205 , 56313872 , 57304498 , 57314089 , 60815357 , 87322653 , 92308986 , 103233471 , 104321551 , 117682518 , 121264498 , 124893555 , 127340623 , 127340624 , 129221764 , 134338484 , 135022769 , 135684653 , 136367931 , 136369166 , 137001852 , 142312486 , 143493338 , 144116012 , 152059722 , 152240379 , 152258737
ChEBI ID CHEBI:175901
ADReCS Drug ID BADD_D01009

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification