Drug ID: D00577

Drug General Information

Drug Name
Quinapril
Synonyms
Ectren; Koretic; Quinaprilum; QUINAPRIL HCL; Quinaprilum [Latin]; Accupril (TN); Quinapril [INN:BAN]; Quinapril (USP/INN); [3S-[2[R*(R*)],3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid; (3S)-2-(N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-{N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Drug Type
Small molecular drug
Indications
Hypertension [ICD-11: BA00-BA04]
Approved
Company
Pfizer Pharmaceuticals
Summary
Quinapril is an ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
Target
Angiotensin-converting enzyme (ACE)
Mechanism of Action: Inhibitor
 T82577

Drug Chemical Infomation and External Links

Download MOL File
Formula
C25H30N2O5
Canonical SMILES
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
InChI
1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1
InChIKey
JSDRRTOADPPCHY-HSQYWUDLSA-N
CAS Number CAS 85441-61-8
TTD ID D0I7SZ
DrugBank ID DB00881
PubChem Compound ID 54892
PubChem Substance ID
9602 , 7980446 , 8145927 , 8149893 , 8183841 , 11335885 , 11361124 , 11364491 , 11367053 , 11369615 , 11372621 , 11374133 , 11377777 , 11462096 , 11484485 , 11488641 , 11491366 , 11492542 , 11495411 , 14759220 , 14881354 , 17397841 , 34718828 , 46506309 , 47589015 , 48035134 , 48259244 , 48416506 , 49835285 , 50065313 , 50113005 , 50113006 , 50744269 , 85787397 , 92309221 , 93166955 , 99301798 , 103590286 , 104306102 , 117576967 , 121264493 , 124893433 , 126683866 , 127334979 , 127334980 , 127334981 , 127334982 , 127334983 , 127334984 , 127334985
ChEBI ID CHEBI:8713
ADReCS Drug ID BADD_D01890

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification