Drug General Information
| Drug Name |
Lovastatin
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| Synonyms |
lovastatin; 75330-75-5; mevinolin; Mevacor; Lovalip; Monacolin K; Lovalord; Mevinacor; Altoprev; Nergadan; Artein; Altocor; 6alpha-Methylcompactin; MK-803; Hipovastin; Lovastatine; Lovasterol; Paschol; Lipivas; Closterol; Teroltrat; Tecnolip; Rovacor; Cholestra; Rodatin; Lozutin; Lipofren; Lestatin; Hipolip; Colevix; Sivlor; Taucor; Lipdip; Belvas; Mevlor; Lovastatine [French]; Lovastatinum [Latin]; Lovastatina [Spanish]; 6-alpha-Methylcompactin; Lovastatinum; Lovastatina; Lovastin; MSD 803; MK 803; 6 alpha-Methylcompactin; UNII-9LHU78OQFD; Altocor; Liposcler; Mevinolin; Rextat; Sivlor;Taucor; Monakolin K; MK803; Advicor (TN); Altocor (TN); Altoprev (TN); L-154803; Lovastatin & Primycin; ML-530B; Mevacor (TN); Mevinolin from Aspergillus sp; Statosan (TN); Lovastatin (USP/INN); Lovastatin [USAN:BAN:INN]; Lovastatin, (1 alpha(S*))-Isomer; Lovastatin, 1 alpha-Isomer (without R*/S* notation); 2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone; 6 Methylcompactin; 6-Methylcompactin; Aspirin/lisinopril/ lovastatin fixed-dose combination
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| Drug Type |
Small molecular drug
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| Indications |
Cardiovascular disease [ICD-11: BA00-BE2Z]
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Phase 3
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|
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Hypercholesterolaemia [ICD-11: 5C80.0]
|
Approved
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| Company |
Atos Pharma
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| Summary |
Lovastatin is an HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke.
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| Target |
HMG-CoA reductase (HMGCR)
Mechanism of Action: Inhibitor
|
T53585 | |
Drug Chemical Infomation and External Links
|
Formula |
C24H36O5
|
| Canonical SMILES |
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
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|
| InChI |
1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
|
|
| InChIKey |
PCZOHLXUXFIOCF-BXMDZJJMSA-N
|
|
| CAS Number | CAS 75330-75-5 | |
| TTD ID | D06WTZ | |
| DrugBank ID | DB00227 | |
| PubChem Compound ID | 53232 | |
| PubChem Substance ID |
9285
,
496591
,
623233
,
855905
,
7734777
,
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48185079
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48334593
,
48413948
,
48416187
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| ChEBI ID | CHEBI:40303 | |
| ADReCS Drug ID | BADD_D01325 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |