Drug General Information
| Drug Name |
Etoposide
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| Synonyms |
etoposide; 33419-42-0; VePesid; Toposar; trans-Etoposide; Lastet; (-)-Etoposide; Zuyeyidal; Etoposidum; Etoposido; Vepesid J; Eposin; Etoposidum [INN-Latin]; Etoposide (VP16); VP 16-213; VP 16 (pharmaceutical); Etoposido [INN-Spanish]; Etopophos (phosphate salt); VP-16-213; 4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside; VP 16213; UNII-6PLQ3CP4P3; NK 171; NSC 141540; CCRIS 2392; HSDB 6517; 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside); EINECS 251-509-1; NSC-141540; Eposide; Etopol; Etosid; Vepeside; Demethyl EpipodophyllotoxinEthylidine Glucoside; E0675; Demethyl-epiodophyllotoxin ethylidene glucoside; Epipodophyllotoxin VP-16213; Eposin (TN); Etopophos (TN); Trans-Etoposide; VePESID (TN); Vepesid (TN); DEMETHY-EPIPODOPHYLLOTOXIN, ETHYLIDENE GLUCOSIDE; VP-16 (TN); Demethylepipodophyllotoxin-beta-D-ethylideneglucoside; Etoposide (JP15/USP/INN); Etoposide [USAN:INN:BAN:JAN]; Eposin, Vepesid, VP-16, Toposar, Etoposide; Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside; Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI); Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside); 4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside; 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside); 4'-Demethylepipodophyllotoxin ethylidene-beta-D-glucoside; 4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin; 4-Demethylepipodophyllotoxin-beta-D-ethylideneglucoside
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| Drug Type |
Small molecular drug
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| Indications |
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
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Approved
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| Company |
Bristol Myers Squibb Co Pharmaceutical Research Institute
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| Summary |
Etoposide is a podophyllotoxin derivative used to treat testicular and small cell lung tumors.
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| Target |
DNA topoisomerase II (TOP2)
Mechanism of Action: Modulator
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T96144 | |
Drug Chemical Infomation and External Links
|
Formula |
C29H32O13
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| Canonical SMILES |
CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
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| InChI |
1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
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| InChIKey |
VJJPUSNTGOMMGY-MRVIYFEKSA-N
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| CAS Number | CAS 33419-42-0 | |
| TTD ID | D0B7EB | |
| DrugBank ID | DB00773 | |
| PubChem Compound ID | 36462 | |
| PubChem Substance ID |
4733
,
597749
,
7847193
,
7979208
,
8145856
,
8174504
,
11110521
,
12013288
,
14886949
,
14935915
,
24278178
,
24769897
,
34677904
,
46386954
,
46500626
,
46505434
,
47362874
,
48182835
,
48332078
,
49681767
,
49699016
,
49855364
,
53787668
,
56463308
,
57311878
,
71825014
,
75974183
,
85148351
,
85788790
,
89850276
,
92308660
,
92308790
,
99437037
,
104019076
,
104234176
,
104324084
,
117664408
,
117682510
,
119525100
,
121363248
,
124349593
,
124659141
,
124757097
,
124800231
,
124893613
,
125163901
,
127298729
,
127298730
,
127298731
,
127298732
|
|
| ChEBI ID | CHEBI:4911 | |
| ADReCS Drug ID | BADD_D00854 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
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| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |