Drug General Information
| Drug Name |
Vinblastine
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| Synonyms |
Nincaluicolflastine; Rozevin; VLB; Vinblastin; Vinblastina; Vinblastinum; Vincaleucoblastin; Vincaleucoblastine; Vincaleukoblastine; Vincoblastine; Vinblastina [DCIT]; VR-8; Vinblastina (TN); Vinblastine (INN); Vinblastine [INN:BAN]; Vinblastinum [INN-Latin]; NDC 0002-1452-01; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE; (2xi,3beta,4'beta,19xi)-vincaleukoblastine; 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indications |
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
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Approved
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| Company |
Eli Lilly And Co
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| Summary |
Vinblastine is a vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
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| Target |
Tubulin beta-2 chain (TUBB2)
Mechanism of Action: Inhibitor
|
T28661 | |
Drug Chemical Infomation and External Links
|
Formula |
C46H58N4O9
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| Canonical SMILES |
CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
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| InChI |
1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
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| InChIKey |
JXLYSJRDGCGARV-CFWMRBGOSA-N
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| CAS Number | CAS 865-21-4 | |
| TTD ID | D0W9MM | |
| DrugBank ID | DB00570 | |
| PubChem Compound ID | 13342 | |
| PubChem Substance ID |
7891062
,
8160040
,
15945566
,
16702846
,
24262986
,
25641143
,
29281493
,
46393695
,
48034812
,
49855966
,
50104049
,
50637221
,
57328088
,
85788295
,
92718122
,
93167219
,
103229487
,
103924566
,
104331509
,
124886802
,
126628575
,
126690312
,
127342232
,
127342233
,
134338070
,
134980402
,
136126664
,
136959342
,
137001867
,
141857134
,
152104919
,
162184753
,
165280031
,
175268513
,
178103457
,
179335179
,
184812178
,
223683512
,
223832241
,
226395766
|
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| ChEBI ID | NA | |
| ADReCS Drug ID | BADD_D02358 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |