Drug General Information
| Drug Name |
Norfloxacin
|
||
| Synonyms |
Baccidal; Barazan; Chibroxin; Fulgram; Lexinor; NFLX; Norflo; Norfloxacine; Norfloxacino; Norfloxacinum; Noroxin; Sebercim; Merck Brand of Norfloxacin; Norfloxacin Merck Brand; AM 0715; AM 715; AM0715; MK 0366; MK 366; MK0366; MK366; AM-0715; AM-715; Chibroxin (TN); Insensye (TN); MK-0366; MK-366; Norflohexal (TN); Norfloxacine [INN-French]; Norfloxacino [INN-Spanish]; Norfloxacinum [INN-Latin]; Norfocin (TN); Noroxin (TN); Nufloxib (TN); Roxin (TN); Utin (TN); Utinor (TN); Apo-Norflox (TN); Norfloxacin (JP15/USP/INN); Norfloxacin [USAN:BAN:INN:JAN]; Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
|
||
| Drug Type |
Small molecular drug
|
||
| Indications |
Bacterial infection [ICD-11: 1A00-1C4Z]
|
Approved
|
|
| Company |
NA
|
||
| Summary |
Norfloxacin is a broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.
|
||
| Target |
Bacterial DNA gyrase (Bact gyrase)
Mechanism of Action: Modulator
|
T22348 | |
Drug Chemical Infomation and External Links
|
Formula |
C16H18FN3O3
|
| Canonical SMILES |
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
|
|
| InChI |
1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
|
|
| InChIKey |
OGJPXUAPXNRGGI-UHFFFAOYSA-N
|
|
| CAS Number | CAS 70458-96-7 | |
| TTD ID | D0Q2PE | |
| DrugBank ID | DB01059 | |
| PubChem Compound ID | 4539 | |
| PubChem Substance ID |
8912
,
597742
,
855614
,
3205552
,
4712110
,
7847277
,
7980171
,
8149451
,
8152796
,
10321598
,
11112831
,
11335259
,
11360498
,
11363911
,
11366473
,
11369035
,
11371707
,
11374005
,
11377197
,
11461470
,
11466249
,
11467369
,
11484909
,
11485918
,
11488833
,
11490340
,
11492268
,
11494831
,
12013332
,
14715876
,
14874649
,
26611845
,
26680206
,
26746929
,
26746930
,
29223630
,
46508634
,
47440088
,
47440089
,
47440090
,
47515159
,
47736303
,
47736304
,
47810598
,
47959570
,
47959571
,
48034947
,
49698389
,
50042536
,
50100528
|
|
| ChEBI ID | CHEBI:100246 | |
| ADReCS Drug ID | BADD_D01587 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |