Drug General Information
| Drug Name |
Loratadine
|
||
| Synonyms |
Aerotina; Alarin; Alavert; Alerpriv; Allertidin; Anhissen; Biloina; Bonalerg; Civeran; Claratyne; Clarinase; Claritin; Claritine; Clarityn; Clarityne; Clarium; Fristamin; Histaloran; Lergy; Lertamine; Lesidas; Lisino; Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina; Loratadinum; Loratidine; Loratyne; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinomex; Roletra; Sanelor; Sensibit; Sohotin; Tadine; Velodan; Versal; Zeos; Bedix Loratadina; Claratyne Cold; Claratyne Decongestant; Clarinase Reperabs; Claritin D; Claritin Hives Relief; Claritin Hives Relief Reditab; Claritin Reditabs; Claritin reditab; Clarityne Dy Repetabs; Loratadina [Spanish]; Loratadine Redidose; Loratadine Wyeth Brand; Loratadinum [Latin]; Sinhistan Dy; Talorat Dy; Wyeth Brand of Loratadine; L 9664; Sch 29851; Sch29851; Alavert (TN); AllergyX (TN); Children's Claritin; Claritin (TN); Claritine (TN); Clarityn (TN); Clarityne (TN); Clarityne-D; Flonidan (TN); Fristamin (TN); Lomilan (TN); Lorfast (TN); Rinolan (TN); Roletra (TN); Sch-29851; Symphoral (TN); Tidilor (TN); Alavert, Claritin, Loratadine; Loratadine [USAN:BAN:INN]; Loratadine (JAN/USAN/INN); Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate; 1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester; 1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester; 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester; 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acidethyl ester; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
|
||
| Drug Type |
Small molecular drug
|
||
| Indications |
Allergic rhinitis [ICD-11: CA08.0]
|
Discontinued in Phase 2
|
|
|
Allergy [ICD-11: 4A80-4A85]
|
Approved
|
||
| Company |
Schering-Plough Corporation
|
||
| Summary |
Loratadine is a second generation antihistamine used to manage the symptoms of allergic rhinitis.
|
||
| Target |
Histamine H1 receptor (H1R)
Mechanism of Action: Antagonist
|
T77913 | |
Drug Chemical Infomation and External Links
|
Formula |
C22H23ClN2O2
|
| Canonical SMILES |
CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
|
|
| InChI |
1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
|
|
| InChIKey |
JCCNYMKQOSZNPW-UHFFFAOYSA-N
|
|
| CAS Number | CAS 79794-75-5 | |
| TTD ID | D06ABF | |
| DrugBank ID | DB00455 | |
| PubChem Compound ID | 3957 | |
| PubChem Substance ID |
535878
,
855843
,
1197563
,
4964188
,
7847430
,
7979793
,
8150042
,
8152484
,
11111394
,
11113345
,
11335967
,
11361206
,
11364390
,
11366952
,
11369514
,
11371620
,
11373832
,
11377676
,
11445825
,
11462178
,
11485284
,
11489400
,
11490556
,
11491992
,
11495310
,
11528699
,
12013131
,
14804759
,
17405241
,
24278525
,
25623638
,
26612522
,
26680506
,
26719690
,
26747010
,
26751528
,
29223071
,
46386837
,
46507853
,
47365230
,
48035159
,
48110481
,
48110482
,
48259268
,
48416183
,
49835216
,
49846690
,
50100268
,
50104102
,
50104103
|
|
| ChEBI ID | CHEBI:6538 | |
| ADReCS Drug ID | BADD_D01317 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |