Drug General Information
| Drug Name |
Imipramine
|
||
| Synonyms |
Antideprin; Berkomine; Censtim; Censtin; Declomipramine; Dimipressin; Dpid; Dynaprin; Eupramin; Imavate; Imidobenzyle; Imipramin; Imipramina; Imipraminum; Imiprin; Imizin; Imizinum; Impramine; Intalpram; Iramil; Irmin; Janimine; Melipramin; Melipramine; Nelipramin; Norchlorimipramine; Norfranil; Pramine; Prazepine; Promiben;Psychoforin; Surplix; Timolet; Tofranil; Imipramina [Italian]; Tofraniln A; Antideprin (TN); Deprimin (TN); Deprinol (TN); Depsonil (TN); Dyna-zina; Dynaprin (TN); Eupramin (TN); G-22355; Imipramil (TN); Imipramina [INN-Spanish]; Imipramine (INN); Imipramine [INN:BAN]; Imipraminum [INN-Latin]; Irmin (TN); Janimine (TN); Janimine (hydrochloride); Melipramin (TN); SK-Pramine; Surplix (TN); Tofranil(TN); Tofranil (free base); Tofranil (hydrochloride); Tofranil, base; N-(gamma-Dimethylaminopropyl)iminodibenzyl; N-(gamma.-Dimethylaminopropyl)iminodibenzyl; N-(3-Dimethylaminopropyl)-o-iminodibenzyl; 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine; 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine; 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine; 2,2'-(3-Dimethylaminopropylimino)bibenzyl; 2,2'-(3-Dimethylaminopropylimino)dibenzyl; 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine; 5,6-Dihydro-N-(3-(dimethylamino)propyl)-11H-dibenz(b,e)azepine; 5,6-Dihydro-N-[3-(dimethylamino)propyl]-11H-dibenz[b,e]azepine; 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine; 5H-Dibenz(b,f)azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-(9CI)
|
||
| Drug Type |
Small molecular drug
|
||
| Indications |
Depression [ICD-11: 6A70-6A7Z]
|
Approved
|
|
| Company |
Novartis Pharmaceuticals Corp
|
||
| Summary |
Imipramine is a tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
|
||
| Target |
Norepinephrine transporter (NET)
Mechanism of Action: Inhibitor
|
T21945 | |
Drug Chemical Infomation and External Links
|
Formula |
C19H24N2
|
| Canonical SMILES |
CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
|
|
| InChI |
1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
|
|
| InChIKey |
BCGWQEUPMDMJNV-UHFFFAOYSA-N
|
|
| CAS Number | CAS 50-49-7 | |
| TTD ID | D06ZUK | |
| DrugBank ID | DB00458 | |
| PubChem Compound ID | 3696 | |
| PubChem Substance ID |
9261
,
442469
,
615226
,
3249403
,
7548657
,
7849629
,
7979599
,
8152336
,
10524418
,
11111330
,
11111331
,
11335734
,
11360973
,
11363809
,
11366371
,
11368933
,
11371492
,
11373530
,
11377095
,
11461945
,
11466100
,
11467220
,
11484795
,
11485940
,
11488806
,
11490282
,
11491831
,
11494729
,
15222228
,
26751600
,
29214791
,
29222819
,
46507351
,
47365159
,
47588968
,
47736449
,
47736450
,
47736451
,
47810727
,
47885381
,
48110430
,
48110431
,
49698865
,
49761601
,
49961519
,
50100256
,
50104254
,
53788900
,
57288535
,
57321945
|
|
| ChEBI ID | CHEBI:47499 | |
| ADReCS Drug ID | BADD_D01139 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |