Drug General Information
| Drug Name |
Glimepiride
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| Synonyms |
Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P
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| Drug Type |
Small molecular drug
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| Indications |
Diabetic complication [ICD-11: 5A2Y]
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Approved
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| Company |
Sanofi-Aventis
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| Summary |
Glimepiride is a sulfonylurea drug used to treat type 2 diabetes mellitus.
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| Target |
ATP-binding cassette transporter C9 (ABCC9)
Mechanism of Action: Blocker
|
T02777 | |
|
ATP-binding cassette transporter C8 (ABCC8)
Mechanism of Action: Blocker
|
T91480 | ||
Drug Chemical Infomation and External Links
|
Formula |
C24H34N4O5S
|
| Canonical SMILES |
CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
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|
| InChI |
1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
|
|
| InChIKey |
WIGIZIANZCJQQY-UHFFFAOYSA-N
|
|
| CAS Number | CAS 261361-60-8 | |
| TTD ID | D0B2GI | |
| DrugBank ID | DB00222 | |
| PubChem Compound ID | 3476 | |
| PubChem Substance ID |
9871
,
5043708
,
7847659
,
7979409
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8145852
,
8152210
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11112876
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12013623
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14908413
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24895093
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,
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47589079
,
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48185080
,
48334594
,
49648856
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49699123
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49731995
,
49835734
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50037704
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50126308
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56313637
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57321825
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77374551
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81040871
,
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85787655
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85787837
,
91613422
,
92125647
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92308643
,
92309214
,
92711714
,
99344865
,
99437102
,
103394534
,
103543151
,
103913636
,
104171333
,
104303626
|
|
| ChEBI ID | CHEBI:5383 | |
| ADReCS Drug ID | BADD_D01023 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |