Drug ID: D00127

Drug General Information

Drug Name
Domperidone
Synonyms
Domperidon; Domperidona; Domperidonum; Motilium; Nauzelin; KW 5338; NCI299589; Costi (TN); D-122; Domperidona [INN-Spanish]; Domperidonum [INN-Latin]; HS-0067; KW-5338; Motilium (TN); Motillium (TN); Motinorm (TN); R 33,812; R-33812; R-33,812; Domperidone (JAN/USAN/INN); Domperidone [USAN:BAN:INN:JAN]; 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine; 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone; 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone; 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Drug Type
Small molecular drug
Indications
Gastrointestinal disease [ICD-11: DE2Z]
Approved
Company
Janssen Pharmaceutica
Summary
Domperidone is a dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting.
Target
Dopamine D2 receptor (D2R)
Mechanism of Action: Antagonist
 T67162

Drug Chemical Infomation and External Links

Download MOL File
Formula
C22H24ClN5O2
Canonical SMILES
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
InChI
1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
InChIKey
FGXWKSZFVQUSTL-UHFFFAOYSA-N
CAS Number CAS 57808-66-9
TTD ID D0AV3G
DrugBank ID DB01184
PubChem Compound ID 3151
PubChem Substance ID
147912 , 855562 , 4254117 , 4396595 , 7848808 , 7979120 , 8141008 , 8152006 , 10320029 , 10321742 , 11111029 , 11342096 , 11362279 , 11363285 , 11365847 , 11368409 , 11373493 , 11376571 , 11406905 , 11459105 , 11461219 , 11466489 , 11467609 , 11486237 , 11487681 , 11491902 , 11494205 , 12013334 , 14856268 , 17404990 , 24277911 , 26613181 , 26653336 , 26746912 , 26746913 , 26751449 , 29222293 , 46500486 , 46508314 , 47216928 , 47291272 , 47291273 , 47959936 , 48334655 , 48334656 , 48334657 , 49698821 , 49883248 , 50085997 , 50103922
ChEBI ID CHEBI:31515
ADReCS Drug ID BADD_D00705

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification