Drug General Information
| Drug Name |
Busulfan
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| Synonyms |
Busulfano; Busulfanum; Busulfex; Busulphan; Busulphane; Butanedioldimethanesulfonate; Buzulfan; Citosulfan; Glyzophrol; Leucosulfan; Mablin; Methanesulfonic; Mielevcin; Mielosan; Mielucin; Milecitan; Mileran; Misulban; Mitosan; Mitostan; Myeleukon; Myeloleukon; Myelosan; Myelosanum; Mylecytan; Myleran; Mylerlan; Sulfabutin; Sulphabutin; Busulfan GlaxoSmithKline Brand; Busulfan Orphan Brand; Busulfan Wellcome; Busulfan Wellcome Brand; Glaxo Wellcome Brand of Busulfan; GlaxoSmithKline Brand of Busulfan; Myleran tablets; Orphan Brand of Busulfan; Tetramethylene bis[methanesulfonate]; Tetramethylene dimethane sulfonate; Tetramethylenester kyseliny methansulfonove; Tetramethylenester kyseliny methansulfonove[Czech]; Wellcome Brand of Busulfan; AN 33501; CB 2041; GT 2041; GT 41; X 149; Acid, tetramethylene ester; Alkylating agent: crosslinks guanine residues; Busulfan [INN:JAN]; Busulfano [INN-Spanish]; Busulfanum [INN-Latin]; MYLERAN (TN); Methanesulfonic acid, tetram ethylene ester; Methanesulfonic acid, tetramethylene ester; Myleran (TN); Sulfabutin (VAN); Tetramethylene bis(methanesulfonate); Tetramethylene {bis[methanesulfonate]}; Wellcome, Busulfan; C.B. 2041; G.T. 41; Myleran, Busulfex, Busulfan; Busulfan (JP15/USP/INN); Butane-1,4-diyl dimethanesulfonate; BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE); N-Butane-1,3-di(methylsulfonate); 1,4-BUTANEDIOL DIMETHANESULFONATE; 1,4-Bis(methanesulfonoxy)butane; 1,4-Bis(methanesulfonyloxy)butane; 1,4-Bis[methanesulfonoxy]butane; 1,4-Butanedi yl dimethanesulfonate; 1,4-Butanediol dimethanesulphonate; 1,4-Butanediol dimethylsulfonate; 1,4-Butanediol, dimethanesulfonate; 1,4-Butanediol, dimethanesulphonate; 1,4-Butanediyl dimethanesulfonate; 1,4-Di(methylsulfonoxy)butane; 1,4-Dimesyloxybutane; 1,4-Dimethane sulfonyl oxybutane; 1,4-Dimethanesulfonoxybutane; 1,4-Dimethanesulfonoxylbutane; 1,4-Dimethanesulfonyloxybutane; 1,4-Dimethanesulphonyloxybutane; 1,4-Dimethylsulfonoxybutane; 1,4-Dimethylsulfonyloxybutane; 1,{4-Bis[methanesulfonoxy]butane}; 4-((Methylsulfonyl)oxy)butyl methanesulfonate; 4-methylsulfonyloxybutyl methanesulfonate
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| Drug Type |
Small molecular drug
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||
| Indications |
Myeloproliferative syndrome [ICD-11: 2A22]
|
Approved
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|
| Company |
GlaxoSmithKline
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| Summary |
Busulfan is an alkylating agent used to treat chronic myelogenous leukemia.
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| Target |
Human Deoxyribonucleic acid (hDNA)
Mechanism of Action: Modulator
|
T86836 | |
Drug Chemical Infomation and External Links
|
Formula |
C6H14O6S2
|
| Canonical SMILES |
CS(=O)(=O)OCCCCOS(=O)(=O)C
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|
| InChI |
1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
|
|
| InChIKey |
COVZYZSDYWQREU-UHFFFAOYSA-N
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|
| CAS Number | CAS 55-98-1 | |
| TTD ID | D07SUG | |
| DrugBank ID | DB01008 | |
| PubChem Compound ID | 2478 | |
| PubChem Substance ID |
9080
,
67633
,
219854
,
3152242
,
4652645
,
7847314
,
7978829
,
8136888
,
8149226
,
8151654
,
10321898
,
11336022
,
11361261
,
11362926
,
11365488
,
11368050
,
11371520
,
11373837
,
11376212
,
11445992
,
11446841
,
11462233
,
11483989
,
11487883
,
11490136
,
11492074
,
11493906
,
11533211
,
15221088
,
17388889
,
17389813
,
24891664
,
26611631
,
26679765
,
26747279
,
26747280
,
26747281
,
26752840
,
29221642
,
46506234
,
47365244
,
47440312
,
47440313
,
48414081
,
48415668
,
48423740
,
48424910
,
48425335
,
49648470
,
49855504
|
|
| ChEBI ID | CHEBI:28901 | |
| ADReCS Drug ID | BADD_D00318 |
Drug-Food (Herb) Interactions
- Drug
- Foods
- Herbs
- Positive
- Negative
- Possible
- Harmful
- No Effect
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship Classification | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Name | Dose | Type | Drug Brand Name | Drug Dose | Drug Dosage Form | Experimental Species | Individuals Number | Test Sample | Ingredient | Effect | Relationship classification |