Drug ID: D00006

Drug General Information

Drug Name
Bupropion
Synonyms
bupropion; Amfebutamone; 34911-55-2; Amfebutamon; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; amfebutamonum; Amfebutamona; (+-)-Bupropion; Wellbatrin; Bupropion [INN:BAN]; 34841-39-9; Elontril; Amfebutamonum [INN-Latin]; Zyban; Amfebutamona [INN-Spanish]; Bupropion SR; AMFEBUTAMONE HCl; alpha-(tert-butylamino)-m-chloropropiophenone; CHEMBL894; BRN 2101062; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; CHEBI:3219; SNPPWIUOZRMYNY-UHFFFAOYSA-N; 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one; Amfebutamon; Amfebutamonum; Elont; Bupropion Hcl; Bupropion hydrocloride; Bupropion (INN); Bupropion (Old RN); Bupropion (USAN); Alpha-(tert-Butylamino)-m-chloropropiophenone; Alpha-(tert-butylamino)-m-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chlorpropiophenon; 1-Propanone; 2-(Tert-Butylamino)-3'-chloropropiophenone
Drug Type
Small molecular drug
Indications
Smoking dependence [ICD-11: 6C4A.2]
Approved
Company
GlaxoSmithKline plc
Summary
Bupropion is a norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation.
Target
Serotonin transporter (SERT)
Mechanism of Action: Inhibitor
 T27812
Norepinephrine transporter (NET)
Mechanism of Action: Inhibitor
 T21945

Drug Chemical Infomation and External Links

Download MOL File
Formula
C13H18ClNO
Canonical SMILES
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C
InChI
1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
InChIKey
SNPPWIUOZRMYNY-UHFFFAOYSA-N
CAS Number CAS 34911-55-2
TTD ID D0X4ZR
DrugBank ID DB01156
PubChem Compound ID 444
PubChem Substance ID
9078 , 794792 , 4652643 , 8150639 , 11342225 , 11362408 , 11364557 , 11367119 , 11369681 , 11371567 , 11374307 , 11377843 , 11407107 , 11466277 , 11467397 , 11485553 , 11485993 , 11487810 , 11489475 , 11490460 , 11492429 , 11495477 , 15196401 , 17425136 , 24438813 , 46386681 , 46506896 , 47217436 , 47440956 , 47515983 , 47515984 , 47589662 , 47960423 , 48335208 , 48415666 , 49681731 , 49698964 , 49832545 , 50023786 , 50105235 , 51091903 , 53786854 , 56313588 , 57320212 , 79472453 , 85209446 , 85788458 , 90340803 , 92308360 , 92308810
ChEBI ID CHEBI:3219
ADReCS Drug ID BADD_D00312

Drug-Food (Herb) Interactions

  • Drug
  • Foods
  • Herbs
  • Positive
  • Negative
  • Possible
  • Harmful
  • No Effect
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship Classification
ID Name Dose Type Drug Brand Name Drug Dose Drug Dosage Form Experimental Species Individuals Number Test Sample Ingredient Effect Relationship classification